Venetoclax penetrates in cerebrospinal fluid and may be effective in chronic lymphocytic leukemia with central nervous system involvement

• Autoři: REDA Gianluigi; CASSIN Ramona; DOVRTĚLOVÁ Gabriela; MATTEO Cristina; GIANNOTTA Juri; D'INCALCI Maurizio; CORTELEZZI Agostino; ZUCCHETTI Massimo
• Rok publikování: 2019
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Haematologica
• Fakulta / Pracoviště MU: Lékařská fakulta
• www: http://www.haematologica.org/content/early/2019/02/07/haematol.2018.213157.abstract
• Doi: http://dx.doi.org/10.3324/haematol.2018.213157
• Klíčová slova: CNS involvement; Chronic Lymphocytic Leukemia; venetoclax
• Popis: Venetoclax, a selective inhibitor of BCL2, has shown promising efficacy in chronic lymphocytic leukemia (CLL) both as single agent or in combination therapy. Central nervous system involvement (CNSi) is a rare complication of CLL and is reported in approximately 0.4% of patients. Therapeutic guidelines have not yet been established and prognosis for these patients is poor. Few cases of CLL with CNSi have been reported until now, and ibrutinib was successfully used due to its ability to penetrate the blood-brain barrier.

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