Function of chromatin structure and dynamics in DNA damage, repair and misrepair: γ-rays andprotons in action

Autoři	JEŽKOVÁ L FALK Martin FALKOVÁ I DAVÍDKOVÁ M BAČÍKOVÁ A ŠTEFANČÍKOVÁ Lenka VACHELOVÁ J Michaelidesová A LUKÁŠOVÁ Emilie BOREYKO A KRASAVIN E KOZUBEK Stanislav
Rok publikování	2014
Druh	Článek v odborném periodiku
Časopis / Zdroj	Applied Radiation and Isotopes
Citace
Doi	http://dx.doi.org/10.1016/j.apradiso.2013.01.022
Popis	According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams.
Související projekty:	Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii