The DNA and RNA sugar–phosphate backbone emerges as the key player. An overview of quantum-chemical, structural biology and simulation studies

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Publikace nespadá pod Pedagogickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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ŠPONER Jiří MLÁDEK Arnošt ŠPONEROVÁ Judit SVOZIL Daniel ZGARBOVÁ Marie BANÁŠ Pavel JUREČKA Petr OTYEPKA Michal

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.ncbi.nlm.nih.gov/pubmed/23072945
Doi http://dx.doi.org/10.1039/c2cp41987d
Obor Biofyzika
Klíčová slova HEPATITIS-DELTA-VIRUS; MOLECULAR-DYNAMICS SIMULATIONS; NUCLEIC-ACID BACKBONE; DENSITY-FUNCTIONAL CALCULATIONS; INTRAMOLECULAR HYDROGEN-BONDS; SINGLE-STRAND BREAKS; INTRINSIC CONFORMATIONAL PROPERTIES; MAIN-GROUP THERMOCHEMISTRY; SELF-CLEAVING RIBOZYMES
Přiložené soubory
Popis Knowledge of geometrical and physico-chemical properties of the sugar–phosphate backbone substantially contributes to the comprehension of the structural dynamics, function and evolution of nucleic acids. We provide a side by side overview of structural biology/bioinformatics, quantum chemical and molecular mechanical/simulation studies of the nucleic acids backbone. We highlight main features, advantages and limitations of these techniques, with a special emphasis given to their synergy. The present status of the research is then illustrated by selected examples which include classification of DNA and RNA backbone families, benchmark structure–energy quantum chemical calculations, parameterization of the dihedral space of simulation force fields, incorporation of arsenate into DNA, sugar–phosphate backbone self-cleavage in small RNA enzymes, and intricate geometries of the backbone in recurrent RNA building blocks. Although not apparent from the current literature showing limited overlaps between the QM, simulation and bioinformatics studies of the nucleic acids backbone, there in fact should be a major cooperative interaction between these three approaches in studies of the sugar–phosphate backbone.
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