Multidrug resistance-associated ABC transporters – too much of one thing, good for nothing

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Publikace nespadá pod Pedagogickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.
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PROCHÁZKOVÁ Jiřina LÁNOVÁ Martina PACHERNÍK Jiří

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Biomolecular concepts
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www URL
Doi http://dx.doi.org/10.1515/bmc-2012-0006
Obor Fyziologie
Klíčová slova ABC transporters; evolution; site mutations
Popis Overexpression of ATP-binding cassette (ABC) transporters in cancer cells results in multidrug resistance (MDR) which leads to unsuccessful chemotherapy. The most important MDR-associated members of ABC superfamily are ABC B1/P-glycoprotein/MDR1, ABC C1/multidrug resistance associated protein 1 (MRP1), and ABC G2/BCRP. This study is not only focused on function, substrates, and localization of these popular proteins but also on other ABC C family members such as ABC C2–6/MRP2-6 and ABC C7/CFTR. Current research is mainly oriented on the cancer-promoting role of these proteins, but important lessons could also be learned from the physiological roles of these proteins or from polymorphisms affecting their function. Thorough knowledge of structure and detailed mechanism of efflux can aid in the discovery of new chemotherapy targets in the future. Although the best way on how to deal with MDR would be to prevent its development, we describe some new promising strategies on how to conquer both inherited and induced MDRs.
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