Small nucleolar RNAs functioning and potential roles in cancer

• Autoři: THORENOOR Nithyananda; SLABÝ Ondřej
• Rok publikování: 2015
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Tumor Biology
• Fakulta / Pracoviště MU: Středoevropský technologický institut
• www: http://link.springer.com/article/10.1007%2Fs13277-014-2818-8
• Doi: http://dx.doi.org/10.1007/s13277-014-2818-8
• Obor: Onkologie a hematologie
• Klíčová slova: cancer; small nucleolar RNAs; non-coding RNAs; GAS5
• Popis: Non-coding RNAs (ncRNAs) are important regu- latory molecules involved in various physiological and path- ological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells. However, recent evi- dence has indicated that these non-coding RNAs might have a crucial role also in controlling cell behavior, and snoRNAs dysfunction could significantly contribute to carcinogenesis. Here, we summarize the most important aspects of snoRNAs biology, their functioning in cancer cell, and potential usage in diagnosis or as a new class of therapeutic targets in cancer.

Související projekty

• CEITEC - středoevropský technologický institut
• Zaměstnáním nejlepších mladých vědců k rozvoji mezinárodní spolupráce