Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish

• Autoři: MACÍKOVÁ Petra; GROH Ksenia J.; AMMANN Adrian A.; SCHIRMER Kristin; SUTER Marc J.-F.
• Rok publikování: 2014
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: ENVIRONMENTAL SCIENCE & TECHNOLOGY
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://pubs.acs.org/doi/abs/10.1021/es502711c
• Doi: http://dx.doi.org/10.1021/es502711c
• Obor: Znečištění a kontrola vody
• Klíčová slova: ENVIRONMENTAL RISK-ASSESSMENT; TANDEM MASS-SPECTROMETRY; SEWAGE-TREATMENT PLANTS; ZEBRAFISH DANIO-RERIO; RAINBOW-TROUT; WASTE-WATER; GLUCOCORTICOID-RECEPTOR; GENE-EXPRESSION; ONCORHYNCHUS-MYKISS; SURFACE WATERS
• Popis: This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 mu g/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from

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