Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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THOMPSON Eric M. HIELSCHER Thomas BOUFFET Eric REMKE Marc LUU Betty GURURANGAN Sridharan MCLENDON Roger E. BIGNER Darell D. LIPP Eric S. PERREAULT Sebastien CHO Yoon-Jae GRANT Gerald KIM Seung-Ki LEE Ji Yeoun RAO Amulya A Nageswara GIANNINI Caterina LI Kay Ka Wai NG Ho-Keung YAO Yu KUMABE Toshihiro TOMINAGA Teiji GRAJKOWSKA Wieslawa A. PEREK-POLNIK Marta LOW David C. Y. SEOW Wan Tew CHANG Kenneth T. E. MORA Jaume POLLACK Ian F. HAMILTON Ronald L. LEARY Sarah MOORE Andrew S. INGRAM Wendy J. HALLAHAN Andrew R. JOUVET Anne FEVRE-MONTANGE Michelle VASILJEVIC Alexandre FAURE-CONTER Cecile SHOFUDA Tomoko KAGAWA Naoki HASHIMOTO Naoya JABADO Nada WEIL Alexander G. GAYDEN Tenzin WATAYA Takafumi SHALABY Tarek GROTZER Michael ZITTERBART Karel ŠTĚRBA Jaroslav KŘEN Leoš HORTOBÁGYI Tibor KLEKNER Almos LÁSZLÓ Bognár PÓCZA Tímea HAUSER Peter SCHÜLLER Ulrich JUNG Shin JANG Woo-Youl FRENCH Pim J. KROS Johan M. VEELEN Marie-Lise C. van MASSIMI Luca LEONARD Jeffrey R. RUBIN Joshua B. VIBHAKAR Rajeev CHAMBLESS Lola B. COOPER Michael K. THOMPSON Reid C. FARIA Claudia C. CARVALHO Alice NUNES Sofia PIMENTEL José FAN Xing MURASZKO Karin M. LÓPEZ-AGUILAR Enrique LYDEN David GARZIA Livia SHIH David J. H. KIJIMA Noriyuki SCHNEIDER Christian ADAMSKI Jennifer NORTHCOTT Paul A. KOOL Marcel JONES David T.W. CHAN Jennifer A. NIKOLIC Ana GARRE Maria Luisa MEIR Erwin G. Van OSUKA Satoru OLSON Jeffrey J. JAHANGIRI Arman CASTRO Brandyn A. GUPTA Nalin WEISS William A. MOXON-EMRE Iska MABBOTT Donald J. LASSALETTA Alvaro HAWKINS Cynthia E. TABORI Uri DRAKE James KULKARNI Abhaya DIRKS Peter RUTKA James T. KORSHUNOV Andrey PFISTER Stefan M. PACKER Roger J. RAMASWAMY Vijay TAYLOR Michael D.

Rok publikování 2016
Druh Článek v odborném periodiku
Časopis / Zdroj Lancet Oncology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1016/S1470-2045(15)00581-1
Obor Onkologie a hematologie
Klíčová slova POSTERIOR-FOSSA TUMORS; CHILDRENS CANCER GROUP; RISK MEDULLOBLASTOMA; RADIATION-THERAPY; ADJUVANT CHEMOTHERAPY; RANDOMIZED-TRIAL; PHASE-III; ONCOLOGY; CHILDHOOD; PATTERNS
Popis Background Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner. Methods We retrospectively identified patients who had a histological diagnosis of medulloblastoma and complete data about extent of resection and survival from centres participating in the Medulloblastoma Advanced Genomics International Consortium. We collected from resections done between April, 1997, and February, 2013, at 35 international institutions. We established medulloblastoma subgroup affiliation by gene expression profiling on frozen or formalin-fixed paraffin-embedded tissues. We classified extent of resection on the basis of postoperative imaging as gross total resection (no residual tumour), near-total resection (< 1.5 cm(2) tumour remaining), or sub-total resection (>= 1.5 cm(2) tumour remaining). We did multivariable analyses of overall survival and progression-free survival using the variables molecular subgroup (WNT, SHH, group 4, and group 3), age (< 3 vs >= 3 years old), metastatic status (metastases vs no metastases), geographical location of therapy (North America/Australia vs rest of the world), receipt of chemotherapy (yes vs no) and receipt of craniospinal irradiation (< 30 Gy or > 30 Gy vs no craniospinal irradiation). The primary analysis outcome was the effect of extent of resection by molecular subgroup and the effects of other clinical variables on overall and progression-free survival. Findings We included 787 patients with medulloblastoma (86 with WNT tumours, 242 with SHH tumours, 163 with group 3 tumours, and 296 with group 4 tumours) in our multivariable Cox models of progression-free and overall survival. We found that the prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. We identified a progression-free survival benefit for gross total resection over sub-total resection (hazard ratio [HR] 1.45, 95% CI 1.07-1.96, p=0.16) but no overall survival benefit (HR 1.23, 0.87-1.72, p=0.24). We saw no progression-free survival or overall survival benefit for gross total resection compared with near-total resection (HR 1.05, 0.71-1.53, p=0.8158 for progression-free survival and HR 1.14, 0.75-1.72, p=0.55 for overall survival). No significant survival benefit existed for greater extent of resection for patients with WNT, SHH, or group 3 tumours (HR 1.03, 0.67-1.58, p=0.89 for sub-total resection vs gross total resection). For patients with group 4 tumours, gross total resection conferred a benefit to progression-free survival compared with sub-total resection (HR 1.97, 1.22-3.17, p= 0.0056), especially for those with metastatic disease (HR 2.22, 1.00-4.93, p= 0.050). However, gross total resection had no effect on overall survival compared with sub-total resection in patients with group 4 tumours (HR 1.67, 0.93-2.99, p= 0.084). Interpretation The prognostic benefit of increased extent of resection for patients with medulloblastoma is attenuated after molecular subgroup affiliation is taken into account. Although maximum safe surgical resection should remain the standard of care, surgical removal of small residual portions of medulloblastoma is not recommended when the likelihood of neurological morbidity is high because there is no definitive benefit to gross total resection compared with near-total resection.
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