Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review

Varování

Publikace nespadá pod Pedagogickou fakultu, ale pod Přírodovědeckou fakultu. Oficiální stránka publikace je na webu muni.cz.

Autoři	HLOUŠKOVÁ Alena BIELIK Peter BONCZEK Ondřej BALCAR Vladimír Josef ŠERÝ Omar
Rok publikování	2017
Druh	Článek v odborném periodiku
Časopis / Zdroj	Neuroendocrinology Letters
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
Obor	ORL, oftalmologie, stomatologie
Klíčová slova	hypodontia; oligodontia; Wnt signal pathway; beta-catenine; tankyrase
Popis	AXIN2 gene plays a crucial role in morphogenesis of craniofacial area and is essential for tooth development. AXIN2 gene is one of the most studied genes associated with tooth agenesis, the most common defect of dentition in humans. Polymorphic variants in AXIN2 gene are discussed in relation to the occurrence of the tooth agenesis but also as an indication of the risk of cancer. Mutations in AXIN2 gene were found in patients with colorectal or hepatocellular carcinoma, prostate cancer, ovarium or lung cancer. These findings support the hypothesis that missing teeth may be a significant marker for predisposition for cancer.
Související projekty:	Molekulární diagnostika hypodoncie a možnosti zubních autotransplantací