Transgenerational phenotype aggravation in CAF-1 mutants reveals parent-of-origin specific epigenetic inheritance

• Název česky: Mezigenerační zhoršování fenotypu v CAF-1 mutantech odhaluje epigenetickou dědičnost závislou na rodiči-původci
• Autoři: MOZGOVÁ Iva; FAJKUS Jiří; WILDHABER Thomas; ROSZAK Pavel; TREJO-ARELLANO Minerva S.; FAJKUS Jiří; ROSZAK Pawel; KOEHLER Claudia; HENNIG Lars
• Rok publikování: 2018
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: New Phytologist
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://www.newphytologist.com
• Doi: http://dx.doi.org/10.1111/nph.15082
• Klíčová slova: Arabidopsis thaliana; CAF-1; Chromatin; Development; DNA methylation; epigenetics; histone
• Popis: Shoot- and root-related growth phenotypes were progressively more affected in successive generations of CAF-1 mutants. Early and late generations of the fasciata (fas)2-4 CAF-1 mutant displayed only limited changes in gene expression, of which increasing upregulation of plant defense-related genes reflects the transgenerational phenotype aggravation. Likewise, global DNA methylation in the sequence context CHG but not CG or CHH (where H = A, T or C) changed over generations in fas2-4. Crossing early and late generation fas2-4 plants established that the maternal contribution to the phenotype severity exceeds the paternal contribution.

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