Negative prognostic significance of primary cilia, CD8+tumor infiltrating lymphocytes and PD1+cells expression in clear cell renal cancer

Varování

Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ROZSYPALOVA Aneta ROSOVA Blanka FILIPOVA Alzbeta NIKOLOV Dimitar Hadzi CHLOUPKOVÁ Renata RICHTER Igor PROKS Jan ZACHOVAL Roman MATEJ Radoslav MELICHAR Bohuslav BUCHLER Tomas DVORAK Josef

Rok publikování 2019
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of BUON
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.ncbi.nlm.nih.gov/pubmed/31646820
Klíčová slova clear cell renal cancer; primary cilia; CD8+tumor infiltrating lymphocytes; programmed cell death protein 1
Popis Purpose: The aim of this study was to investigate the potential association and combined prognostic significance of the frequency of primary cilia (PC), programmed cell death protein-1 receptor (PD1) and CD8+ tumor infiltrating lymphocytes (TIL) in patients with clear cell renal cancer (ccRCC). Methods: The frequency of PC, PD1 expression and the frequency of intratumoral CD8+ TIL were evaluated in 104 ccRCC patients. Results: The median frequency of PC was 0.003. The expression of PD1+ cells were <5% in 52 patients, 5-25% in 34 patients and 26-50% in 13 patients and >50% in 5 patients. Intratumoral CD8+ TIL were evaluable in all patients: negative in 1 patient, <25% in 63, 26-50% in 29 and >50% in 11 patients. Overall survival (OS) according to the frequency of PC was significantly shorter in patients with higher frequency (>= 0.002) than in patients with lower frequency (<0.002) (p<0.001). Median OS was significantly shorter in patients with higher (25%) CD8+ TIL and higher (>25%) PD1+ expression than in patients with lower (<25%) expression (4.6 vs. 97. years, p=0.006 and 2.9 vs. 8.9 years, p=0.006, respectively). Conclusions: The present study provides the first data on the potential association and combined prognostic significance of frequency of PC, PD1+ cells and CD8+ TIL in patients with clear cell renal cancer.
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