Regional Incidence of Inflammatory Bowel Disease in a Czech Pediatric Population: 16 Years of Experience (2002–2017)

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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JABANDŽIEV Petr PINKASOVÁ Tereza KUNOVSKÝ Lumír PAPEŽ Jan JOUZA Martin KARLÍNOVÁ Bára NOVÁČKOVÁ Martina URÍK Milan AULICKÁ Štefánia SLABÝ Ondřej BOHOŠOVÁ Júlia BAJEROVÁ Kateřina BAJER Milan GOEL Ajay

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Pediatric Gastroenterology and Nutrition
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://journals.lww.com/jpgn/FullText/2020/05000/Regional_Incidence_of_Inflammatory_Bowel_Disease.12.aspx
Doi http://dx.doi.org/10.1097/MPG.0000000000002660
Klíčová slova children; Crohn disease; Czech Republic; incidence; inflammatory bowel disease; ulcerative colitis
Popis Objectives: Inflammatory bowel disease (IBD) is today a global disease, the incidence of which is growing in the pediatric population. This prospective study aims to decipher IBD incidence and its trend in a pediatric population through 16 years in the South Moravian Region of the Czech Republic. Methods: We evaluated data concerning 358 pediatric patients with newly diagnosed IBD at University Hospital Brno, which is a gastroenterology center for the entire pediatric population (0-18 years) and cares for all pediatric IBD patients in the South Moravian Region (1,187,667 inhabitants). Results: The study encompassed 3,488,907 children during 16 years. We diagnosed 192 children (53.6%) with Crohn disease (CD), 123 (34.4%) with ulcerative colitis (UC), and 43 (12.0%) with IBD-unclassified (IBD-U). The incidence of IBD increased from 3.8 (CD 2.9, UC 0.9, and IBD-U 0.0) per 100 000/year in 2002 to 14.7 (CD 9.8, UC 4.0, and IBD-U 0.9) per 100,000/year in 2017 (P < 0.001). The overall IBD incidence per 100,000/year was 9.8 (95% confidence interval [CI]: 8.8--10.9). Constituent incidences per 100,000/year were CD 5.2 (95% CI: 4.5--6.0), UC 3.4 (95% CI: 2.8--4.0), and IBD-U 1.2 (95% CI: 0.9--1.6). IBD incidence was projected to reach 18.9 per 100,000/year in 2022. Conclusions: The overall incidence of pediatric IBD in the Czech Republic is increasing, and especially that of CD, whereas trends in UC and IBD-U appear to be constant. These data highlight the need to identify risk factors involved in the rising incidence of IBD.
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