Fibroblasts: The grey eminence of mammary gland development

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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SUMBAL Jakub BELISOVÁ Denisa KOLEDOVÁ Zuzana

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S1084952120301695?via%3Dihub
Doi http://dx.doi.org/10.1016/j.semcdb.2020.10.012
Klíčová slova Breast; Epithelial-stromal interactions; Fibroblast; Heterogeneity; Mammary gland; Microenvironment
Popis The essential role of mammary gland stroma in the regulation of mammary epithelial development, function, and cancer has long been recognized. Only recently, though, the functions of individual stromal cell populations have begun to become more clarified. Mammary fibroblasts have emerged as master regulators and modulators of epithelial cell behavior through paracrine signaling, extracellular matrix production and remodeling, and through regulation of other stromal cell types. In this review article, we summarize the crucial studies that helped to untangle the roles of fibroblasts in mammary gland development. Furthermore, we discuss the origin, heterogeneity, and plasticity of mammary fibroblasts during mammary development and cancer progression.
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