Interplays of different types of epitranscriptomic mRNA modifications

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Publikace nespadá pod Pedagogickou fakultu, ale pod Středoevropský technologický institut. Oficiální stránka publikace je na webu muni.cz.
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RENGARAJ Praveenkumar OBRDLÍK Aleš VUKIĆ Dragana VARADARAJAN Nandan Mysore KEEGAN Liam VAŇÁČOVÁ Štěpánka O'CONNELL Mary Anne

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj RNA Biology
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www https://www.tandfonline.com/doi/full/10.1080/15476286.2021.1969113
Doi http://dx.doi.org/10.1080/15476286.2021.1969113
Klíčová slova Inosine; m(6)A; m(6)A(m); m(5)C; m(1)A; pseudouridine; epitranscriptome; ADAR
Přiložené soubory
Popis Eukaryotic mRNAs are modified by several chemical marks which have significant impacts on mRNA biology, gene expression, and cellular metabolism as well as on the survival and development of the whole organism. The most abundant and well-studied mRNA base modifications are m(6)A and ADAR RNA editing. Recent studies have also identified additional mRNA marks such as m(6)Am, m(5)C, m(1)A and psi and studied their roles. Each type of modification is deposited by a specific writer, many types of modification are recognized and interpreted by several different readers and some types of modifications can be removed by eraser enzymes. Several works have addressed the functional relationships between some of the modifications. In this review we provide an overview on the current status of research on the different types of mRNA modifications and about the crosstalk between different marks and its functional consequences.
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