DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS
| Autoři | |
|---|---|
| Rok publikování | 2022 |
| Druh | Článek ve sborníku |
| Konference | Czech Chemical Society Symposium Series |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.ccsss.cz/index.php/ccsss/issue/view/31/45 |
| Klíčová slova | HDAC inhibitors_N-Hydroxy-cinnamide_derivates cancer |
| Popis | Histone deacetylases (HDACs) are enzymes involved in regulating fundamental cellular processes, such as cell cycle progression, differentiation, and tumorigenesis. The abnormal function of HDACs can induce various severe human diseases, including cancer, pulmonary disease, and neurodegenerative disorders. HDAC inhibitors (HDACi), which form a complex with the Zn2+ ion in the catalytic pocket of enzymes, have considerable anticancer activity. The docking study was performed using AutoDock Vina 1.2.0. program. The predicted binding affinity for HDAC enzymes suggests the high potential of the compounds tested. Biological tests confirmed the results of molecular docking. |
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