Evolutionary Processes in the Emergence and Recent Spread of the Syphilis Agent, Treponema pallidum

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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PLA-DIAZ Marta SANCHEZ-BUSO Leonor GIACANI Lorenzo ŠMAJS David BOSSHARD Philipp P BAGHERI Homayoun C SCHUENEMANN Verena J NIESELT Kay ARORA Natasha GONZALEZ-CANDELAS Fernando

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Molecular Biology and Evolution
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://academic.oup.com/mbe/article/39/1/msab318/6427636?login=true
Doi http://dx.doi.org/10.1093/molbev/msab318
Klíčová slova recombination; selection; phylogenetic congruence; treponematoses; genome analysis
Popis The incidence of syphilis has risen worldwide in the last decade in spite of being an easily treated infection. The causative agent of this sexually transmitted disease is the bacterium Treponema pallidum subspecies pallidum (TPA), very closely related to subsp. pertenue (TPE) and endemicum (TEN), responsible for the human treponematoses yaws and bejel, respectively. Although much focus has been placed on the question of the spatial and temporary origins of TPA, the processes driving the evolution and epidemiological spread of TPA since its divergence from TPE and TEN are not well understood. Here, we investigate the effects of recombination and selection as forces of genetic diversity and differentiation acting during the evolution of T. pallidum subspecies. Using a custom-tailored procedure, named phylogenetic incongruence method, with 75 complete genome sequences, we found strong evidence for recombination among the T. pallidum subspecies, involving 12 genes and 21 events. In most cases, only one recombination event per gene was detected and all but one event corresponded to intersubspecies transfers, from TPE/TEN to TPA. We found a clear signal of natural selection acting on the recombinant genes, which is more intense in their recombinant regions. The phylogenetic location of the recombination events detected and the functional role of the genes with signals of positive selection suggest that these evolutionary processes had a key role in the evolution and recent expansion of the syphilis bacteria and significant implications for the selection of vaccine candidates and the design of a broadly protective syphilis vaccine.
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