Single-center long-term results of vagus nerve stimulation for pediatric epilepsy: a 10-17-year follow-up study

Varování

Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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CHRASTINA Jan HORÁK Ondřej RYZÍ Michal BRÁZDIL Milan NOVÁK Zdeněk ZEMAN Tomáš DANHOFER Pavlína

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Childs nervous system
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://link.springer.com/article/10.1007/s00381-023-05992-3
Doi http://dx.doi.org/10.1007/s00381-023-05992-3
Klíčová slova Seizure; Stimulation treatment; Stimulation responder; Palliative surgery
Popis PurposeA retrospective study, based on a prospectively built database, presents the results of long-term follow-up care of pediatric vagus nerve stimulation (VNS) patients in terms of seizure outcome, surgical aspects, the potential impact of maturation, and medication changes.MethodsFrom a prospectively built database, 16 VNS patients (median age 12.0 years, range 6.0 to 16.0 years; median seizure duration 6.5 years, range 2.0 to 15.5 years) followed for at least 10 years were graded as non-responder - NR (seizure frequency reduction < 50%), responder - R (reduction >= 50% and < 80%), and 80% responder - 80R (reduction >= 80%). Data about surgical aspects (battery replacement, system complications), seizure dynamics, and medication changes were taken from the database.ResultsThe early percentages of good results (80R + R) were 43.8% (year 1), 50.0% (year 2), and 43.8% (year 3). These percentages remained stable between years 10 and 12 (50% year 10; 46.7% year 11; 50% year 12) and increased in years 16 (60%) and 17 (75%). Depleted batteries were replaced in ten patients, six of whom were either R or 80R. In the four NR, the indication for replacement was improved quality of life. Three patients had VNS explanted or switched off-one had repeated asystolia and two were NR. The effect of hormonal changes in menarche on seizure was not proven. During the study, antiseizure medication was changed in all patients.ConclusionsThe study proved the efficacy and safety of VNS in pediatric patients over an exceptionally long follow-up period. The demand for battery replacements indicates a positive treatment effect.
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