Nanodiamonds as artificial proteins for regulation of a cell signalling system
| Autoři | |
|---|---|
| Rok publikování | 2023 |
| Druh | Patent |
| Fakulta / Pracoviště MU | |
| Vydavatel | United States Patent and Trademark Office |
| Stát vydání | Spojené státy americké |
| Číslo patentu | US11744855B2 |
| www | Link na PDF dokument na stránkách Google Patents |
| Popis | Here, we show that nanosized diamond crystals (nanodiamonds, NDs) without any synthetically installed (bio)organic interface enable the specific and efficient targeting of the family of extracellular signalling molecules known as fibroblast growth factors (FGFs). We found that at certain conditions the ND strongly associate with multiple FGF ligands present at sub-nanomolar concentrations and effectively neutralize the effects of FGF signalling in cells without interfering with other growth factor systems and serum proteins unrelated to FGFs. |
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