Influence of metabolic state and body composition on the action of pharmacological treatment of migraine

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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BRUIJN Noor ROMY van Lohuizen BORON Malgorzata FITZEK Mira GABRIELE Francesca GIULIANI Giada MELGAREJO Laura ŘEHULKA Pavel SEBASTIANELLI Gabriele TRILLER Paul VIGNERI Simone OZCAN Behiye MAASSEN van den Brink Antoinette

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj JOURNAL OF HEADACHE AND PAIN
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.mdpi.com/2227-9059/12/2/404
Doi http://dx.doi.org/10.1186/s10194-024-01724-3
Klíčová slova CGRP; Metabolic disorders; Diabetes mellitus; Migraine; Obesity; Lifestyle
Popis Migraine is a disabling neurovascular disorder among people of all ages, with the highest prevalence in the fertile years, and in women. Migraine impacts the quality of life of affected individuals tremendously and, in addition, it is associated with highly prevalent metabolic diseases, such as obesity, diabetes mellitus and thyroid dysfunction. Also, the clinical response to drugs might be affected in patients with metabolic disease due to body composition and metabolic change. Therefore, the efficacy of antimigraine drugs could be altered in patients with both migraine and metabolic disease. However, knowledge of the pharmacology and the related clinical effects of antimigraine drugs in patients with metabolic disease are limited. Therefore, and given the clinical relevance, this article provides a comprehensive overview of the current research and hypotheses related to the influence of metabolic state and body composition on the action of antimigraine drugs. In addition, the influence of antimigraine drugs on metabolic functioning and, vice versa, the influence of metabolic diseases and its hormonal modulating medication on migraine activity is outlined. Future exploration on personalizing migraine treatment to individual characteristics is necessary to enhance therapeutic strategies, especially given its increasing significance in recent decades.
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