Deterministic modeling of the chromatin organization in human cell nuclei

Varování

Publikace nespadá pod Pedagogickou fakultu, ale pod Fakultu informatiky. Oficiální stránka publikace je na webu muni.cz.
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VORÁČEK Jan KOZUBEK Michal BÁRTOVÁ Eva MANNIO Markus

Rok publikování 2001
Druh Článek ve sborníku
Konference Shaping future with simulation
Fakulta / Pracoviště MU

Fakulta informatiky

Citace
www abstract
Obor Využití počítačů, robotika a její aplikace
Klíčová slova classification; chromosomes; fluorescence
Popis Hitherto unpublished technique for prospective diagnostics of deleterious human diseases based on the generalization of the chromatin organization in human cell nuclei is introduced. Its principle is in the interaction with a model derived from image data, which are collected by the fully automated high resolution cytometer. The most significant topological descriptors of the cell nuclei are selected and processed in the inductive learning system. In its training phase the cytological properties of the analyzed cell as well as all the external stimuli are known and used for the proper adaptation. Then the resultant structure serves as a classifier categorizing unknown biological material in accordance with internal structure or parameters. Format of the input data and possible approaches to the problem formalization are presented and documented with several examples. Lastly, the experimental results are discussed and future research directions are suggested.
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