Structural studies of benzophenanthridine alkaloid free bases by NMR spectroscopy

• Autoři: SEČKÁŘOVÁ Pavlína; MAREK Radek; DOSTÁL Jiří; DOMMISSE Roger; ESMANS Eddy L.
• Rok publikování: 2002
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: Magnetic Resonance in Chemistry
• Fakulta / Pracoviště MU: Přírodovědecká fakulta
• www: http://www3.interscience.wiley.com/cgi-bin/abstract/88512831/START
• Obor: Organická chemie
• Klíčová slova: NMR; 1H NMR; 13C NMR; benzophenanthridine alkaloids; free base formation; GHMBC; GSQMBC; pseudobases
• Popis: The free bases of eight quaternary benzo[c]phenanthridine alkaloids were investigated by 1H and 13C NMR spectroscopy. The pseudobases (the 6-hydroxy-5,6-dihydro derivatives) were found to be the only products of the alkalization in DMSO-d6 solution. In less polar solvents the formation of the bimolecular aminoacetal structure is preferred. In biological systems, free bases of the alkaloids are assumed to adopt the pseudobase structure.

Související projekty

• Biomolekulární centrum