Pharmacological manipulation with 5-HT2 receptor subtype affects methamphetamine i.v. self-administration in rats
| Autoři | |
|---|---|
| Rok publikování | 2003 |
| Druh | Článek ve sborníku |
| Konference | Abstract Book of Sixth IBRO World Congress of Neuroscience |
| Fakulta / Pracoviště MU | |
| Citace | |
| Obor | Farmakologie a lékárnická chemie |
| Klíčová slova | 5-HT2 receptor subtype; alpha-methyl-serotonin; methamphetamine; i.v. self-administration; rats |
| Popis | In the present study, modulation of the reinforcing effects of methamphetamine by the non-selective 5-HT2 receptor agonist alpha-methyl-serotonin was ascertained using the method of i.v. self-administration in rats. In summary, our findings suggest that 5-HT2 receptor activation might attenuate methamphetamine self-administration. These results are in accordance with the findings of Munzar et al. (1999) indicating that 5-HT mediation of discriminative stimulus actions of methamphetamine appears to be involved to a big extent in stimulation at 5-HT2A/2C receptors. |
| Související projekty: |