Whole Genome Sequences of Three Treponema pallidum ssp. pertenue Strains: Yaws and Syphilis Treponemes Differ in Less than 0.2% of the Genome Sequence

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Publikace nespadá pod Pedagogickou fakultu, ale pod Lékařskou fakultu. Oficiální stránka publikace je na webu muni.cz.
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ČEJKOVÁ Darina ZOBANÍKOVÁ Marie CHEN Lei POSPÍŠILOVÁ Petra STROUHAL Michal QIN Xiang MIKALOVÁ Lenka NORRIS Stephen J. MUZNY Donna M. GIBBS Richard A. FULTON Lucinda L. SODERGREN Erica WEINSTOCK George M. ŠMAJS David

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj PLoS Neglected Tropical Diseases
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www Art.No. e1471
Doi http://dx.doi.org/10.1371/journal.pntd.0001471
Obor Mikrobiologie, virologie
Klíčová slova Treponema pallidum; Syphilis; Genome; Yaws
Popis Spirochete Treponema pallidum ssp. pertenue (TPE) is the causative agent of yaws while strains of Treponema pallidum ssp. pallidum (TPA) cause syphilis. Both yaws and syphilis are distinguished on the basis of epidemiological characteristics and clinical symptoms. Neither treponeme can reproduce outside the host organism, which precludes the use of standard molecular biology techniques used to study cultivable pathogens. In this study, we determined high quality whole genome sequences of TPE strains and compared them to known genetic information for T. pallidum ssp. pallidum strains. The genome structure was identical in all three TPE strains and also between TPA and TPE strains. The TPE genome length ranged between 1,139,330 bp and 1,139,744 bp. The overall sequence identity between TPA and TPE genomes was 99.8%, indicating that the two pathogens are extremely closely related. A set of 34 TPE genes (3.5%) encoded proteins containing six or more amino acid replacements or other major sequence changes. These genes more often belonged to the group of genes with predicted virulence and unknown functions suggesting their involvement in infection differences between yaws and syphilis.
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