Speeding up Mass Spectrometry Imaging with fast Precision Mirror Scanning

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Authors	BEDNAŘÍK Antonín KUBA Pavel HOUŠKA Pavel TOMALOVÁ Iva MOSKOVETS Eugene PREISLER Jan
Year of publication	2012
Type	Article in Proceedings
Conference	CECE 2012
MU Faculty or unit	Central European Institute of Technology
Citation
Web	http://www.ce-ce.org/cece2012/Proceedings%20CECE%202012%20Final+late%20abstracts_web.pdf
Field	Analytic chemistry
Keywords	mass spectrometry imaging; MALDI TOF MSI
Description	MALDI mass spectrometry imaging (MALDI MSI) is one of the most rapidly evolving techniques in the field of mass spectrometry. This technique holds a great potential in biomarker discovery, drug distribution analysis and in biosciences generally. Hand in hand with new and more demanding applications a need of new high-throughput instrumentation arises. Though a 1 kHz lasers generation of mass spectrometers brought significant decrease of MSI time, a single high resolution image (10 000 pixels) acquisition can still consume many hours. Here we introduce an incorporation of a high speed scanning mirror redirecting the desorbing laser as a possible way to increase the MSI performance.
Related projects:	Analýza biomolekul hmotnostní spektrometrií s laserovou desorpcí/ionizací za účasti nanomateriálů CEITEC - Central European Institute of Technology