Speeding up Mass Spectrometry Imaging with fast Precision Mirror Scanning

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Authors

BEDNAŘÍK Antonín KUBA Pavel HOUŠKA Pavel TOMALOVÁ Iva MOSKOVETS Eugene PREISLER Jan

Year of publication 2012
Type Article in Proceedings
Conference CECE 2012
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.ce-ce.org/cece2012/Proceedings%20CECE%202012%20Final+late%20abstracts_web.pdf
Field Analytic chemistry
Keywords mass spectrometry imaging; MALDI TOF MSI
Description MALDI mass spectrometry imaging (MALDI MSI) is one of the most rapidly evolving techniques in the field of mass spectrometry. This technique holds a great potential in biomarker discovery, drug distribution analysis and in biosciences generally. Hand in hand with new and more demanding applications a need of new high-throughput instrumentation arises. Though a 1 kHz lasers generation of mass spectrometers brought significant decrease of MSI time, a single high resolution image (10 000 pixels) acquisition can still consume many hours. Here we introduce an incorporation of a high speed scanning mirror redirecting the desorbing laser as a possible way to increase the MSI performance.
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