VLIV DLOUHODOBÉ APLIKACE HALOPERIDOLU NA ELEKTROGRAM IZOLOVANÉHO SRDCE A EXPRESI SIGMA 1 A IP3 RECEPTORŮ U MORČETE

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Title in English	EFFECT OF LONG-TERM APPLICATION OF HALOPERIDOL ON ELECTROGRAM OF ISOLATED HEART AND EXPRESSION OF SIGMA 1 AND IP3 RECEPTORS IN GUINEA PIG
Authors	STRAČINA Tibor NOVÁKOVÁ Marie MASAŘÍK Michal
Year of publication	2012
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Our work was focused on effect of long-term application of haloperidol on electrogram of isolated heart and expression of sigma 1 and IP3 receptors in guinea pig. We showed that expression of sigma 1 receptors was increased in atria of the heart after long-term application of haloperidol. Withal, the spontaneous heart rate was decreased, the QT interval of electrogram was extended and incidence of supraventricular extrasystoles was increased.
Related projects:	Studium mechanismů vzniku některých kardiovaskulárních onemocnění