miR-17-5p Regulates Endocytic Trafficking through Targeting TBC1D2/Armus

• Authors: SERVA Andrius; KNAPP Bettina; TSAI Yueh-Tso; CLASS Christoph; LISAUSKAS Tautvydas; MATULA Petr; HARDER Nathalie; KADERALI Lars; ROHR Karl; ERFLE Holger; EILS Roland; BRAGA Vania; STARKUVIENE Vytaute
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: PLoS One
• MU Faculty or unit: Faculty of Informatics
• Doi: http://dx.doi.org/10.1371/journal.pone.0052555
• Field: Use of computers, robotics and its application
• Keywords: Cancer cell-proliferation; epidermal-grow-factor; endosomal traficking; application of image analysis
• Description: We have developed an image analysis approach for segmentation and classification of cell nuclei that was used in a study of the regulation of endocytic trafficking. A novel function of miR-17 was discovered, which might act cooperatively with other functions of miR-17 and related miRNAs in health and disease.

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