Vaskulární endoteliální růstový faktor

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Title in English Vascular endothelial growth factor
Authors

KAISER Radek DUBOVÝ Petr HANINEC Pavel

Year of publication 2011
Type Article in Periodical
Magazine / Source Československá fyziologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Neurology, neurosurgery, neurosciences
Keywords VEGF; growth factor; angiogenesis; neuroproliferation; neuroprotection
Description VEGF, vascular endothelial growth factor, is a substance firstly described in 1983 as a tumor-secreted protein which causes the development of ascitic fluid in case of abdominal tumors. Its influence on angiogenesis was ascertained by many studies. The strongest stimulus for its production is hypoxia, which leads to higher secretion of VEGF and new angiogenesis of so affected tissue. The neurogenic effect was firstly mentioned in 1999. Its protective and pro- liferative influence both on CNS and peripheral nerves is now widely accepted. It was demonstrated that VEGF has more wide ranging effect than previously thought.
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