Využití moderních DNA metod ve výzkumu molekulárních příčin hypodoncie
| Title in English | Modern DNA methods in the research of molecular causes of hypodontia |
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| Authors | |
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Ortodoncie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.orthodont-cz.cz/modul/casopis_clanek/soubory/Clanek-Ortodoncie-03-2013-04.pdf |
| Field | Physiology |
| Keywords | mutation; polymorphism; gene; PAX9; MSX1; DNA; oligodontia; hypodontia; tooth agenesis |
| Description | Disturbances of cell differentiation in dentition development are cause of tooth agenesis. Until now, tens of mutations involved in gene expression related to dentition development were found. They are mutations mainly in PAX9, MSX1 and AXIN2 genes. The research on the influence of gene mutations involved in the dentition development is based on the DNA sequencing of primarily translated sequences. Capillary sequencing instruments of first generation were mainly used in the research until now. Their use is limited by cost and by laboriouness. Last years bring new sequencing methods (II. generation) with cheaper analyses and possibilities to make sequencing of larger DNA segments. The aim of this paper is a summary of the current knowledge about research manner of influence of gene mutations on dentition development. |
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