Antitumour activities of sanguinarine and related alkaloids
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Periodical |
| Magazine / Source | Phytochemistry reviews |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1007/s11101-013-9290-8 |
| Field | Genetics and molecular biology |
| Keywords | Apoptosis; Anti-proliferative activity; Benzophenanthridine alkaloids; cancer; sanguinarine |
| Description | Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy. |
| Related projects: |