Antitumour activities of sanguinarine and related alkaloids

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

SLANINOVÁ Iva PĚNČÍKOVÁ Kristýna KANTOROVÁ Jana SLANINA Jiří TÁBORSKÁ Eva

Year of publication 2014
Type Article in Periodical
Magazine / Source Phytochemistry reviews
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s11101-013-9290-8
Field Genetics and molecular biology
Keywords Apoptosis; Anti-proliferative activity; Benzophenanthridine alkaloids; cancer; sanguinarine
Description Sanguinarine is a best-known member of a relatively small group of quaternary benzo[c]phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae and, to a limited extent, in some species of the families Fumariaceae and Rutaceae. From a medical perspective, QBAs have many important properties. In addition to antitumour activity, they display antimicrobial, antifungal and anti-inflammatory effects. They may interact with many targets, such as DNA and microtubules, and they modify the activities of a wide variety of enzymes. This review summarises the current state of knowledge about the properties of QBAs that are important for their potential use in anticancer therapy.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.