Studie možnosti mapování vybraných léčiv v mozkové tkáni myší pomocí MALDI MS

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Title in English	Study of MALDI MS imaging of selected drugs in brain tissue of mice
Authors	JÄGEROVÁ Kateřina BEDNAŘÍK Antonín NILSSON Christian POKORNÁ Soňa ILKOVICS Ladislav HAMPL Aleš PISTOVČÁKOVÁ Jana DEMLOVÁ Regina PREISLER Jan
Year of publication	2013
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Matrix-assisted laser desorotion/ionization mass spektrometry (MALDI-MS) is a technique allowing the visualization of the distribution of analytes variety in diverse samples, typicaly in thin sections of biological tissue. This method has been successfully used to the analysis of brain tissues, monitoring of drugs distribution and drugs metabolites in tissues, and in new biomarkers investigation. In this paper, we research the imaging of selected drugs distribution - olanzapin, haloperidol and paliperidone in tissue of mice brain using MALDI MS.
Related projects:	CEITEC - Central European Institute of Technology Nové strategie úpravy vzorků pro desorpční hmotnostní spektrometrii Zaměstnáním čerstvých absolventů doktorského studia k vědecké excelenci