Způsob přímé mono-N-substituce piperazinu

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Title in English	Method of piperazine direct mono-N-substitution
Authors	PAZDERA Pavel ZBEROVSKÁ Barbora NĚMEČKOVÁ Dana
Year of publication	2014
Type	Patent
MU Faculty or unit	Faculty of Science
Publisher
State	Czech Republic
Patent's number	304520
Web	http://isdv.upv.cz/portal/pls/portal/portlets.pts.det?xprim=1847729&lan=cs
Description	The solution provides a method for the direct, mono-N-substitution in the synthetically significant yields in a simple embodiment, in which is prepared piperazin-1-ium cation and subsequently catalyzed compound d-metal, aluminum or cerium reacting piperazine-1-ium cation electrophile i. e. nitrourea agent, preferably in a molar ratio of piperazine-1-ium cation to electrophilic reagent in the range of 1:1 to 1:1.4.
Related projects:	New catalysts and reagents for sustainable green syntheses and combinatorial syntheses