AN ELECTROCHEMICAL STUDY OF d(GCGAAGC) DNA HEPTAMER AND ITS SEQUENTIAL ANALOGUES

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Authors

PILAŘOVÁ Iveta VORLÍČKOVÁ Michaela KEJNOVSKÁ Iva TRNKOVÁ Libuše

Year of publication 2014
Type Article in Proceedings
Conference Sborník příspěvků XIV. Pracovní setkání fyzikálních chemiků a elektrochemiků
MU Faculty or unit

Faculty of Science

Citation
Web Sborník příspěvků XIV. Pracovní setkání fyzikálních chemiků a elektrochemiků
Field Physical chemistry and theoretical chemistry
Keywords hairpins; quadruplexes; i-motifs; cyclic voltammetry; elimination voltammetric procedure
Description DNA molecules can adopt many unusual structures (hairpins, i-motifs, G – quadruplexes and others), linked with many neurodegenerative diseases (X syndrome, Friedreich’s ataxia, Huntington’s disease). The aim of our contribution is the electrochemical investigation of different structures of DNA heptamers with AAA, CCC, GAA, GGG and TTT sequence in the molecule center as the effect of adsorption on the electrode surface (mercury electrode, pencil graphite electrode).
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