DOMINO SYNTHESIS OF SOME NITROGEN CONTAINING HETEROCYCLES CATALYZED BY SOLID SUPPORTED Ce(III) SYSTEM

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Science. Official publication website can be found on muni.cz.
Authors

HAVRÁNKOVÁ Eva PAZDERA Pavel

Year of publication 2013
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description One of the possibilities to sophisticate compound syntheses is catalysis using supported catalyst which combines the advantages of both homogeneous and heterogeneous catalyst. An application of Ce(III) inorganic salts, first of all CeCl3.7H2O doped by sodium iodide, not until has been described from start of 21st Century. Twenty communications has been present during this time only. Catalysis by Ce(III) salts has been used for an activation of carbonyl compounds and their derivatives in syntheses. Easily available, cheap and mechanically and thermally stable industrial cation-exchangers may be used as carriers1. These in connection with complex of cerium in oxidation state of 3+ provide an effective, easily separable and recyclable catalytic system. This system has been studied with a view to its possible synthetic applications on model domino syntheses, i.e. three-component four-step domino synthesis of substituted 1,5- benzodiazepines2, and three-component four-step domino synthesis of substituted 3,4- dihydropyrimidin-2(1H)-ones3, respectively. It has been discovered that cation Ce(III) supported on a weak acid macroporous cation-exchanger has shown in the studied reactions at least the same or better catalytic activity as salt CeCl3.7H2O, eventually doped by NaI.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.