Endocrine Disrupting Compounds Affecting Corticosteroid Signaling Pathways in Czech and Swiss Waters: Potential Impact on Fish

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Authors

MACÍKOVÁ Petra GROH Ksenia J. AMMANN Adrian A. SCHIRMER Kristin SUTER Marc J.-F.

Year of publication 2014
Type Article in Periodical
Magazine / Source ENVIRONMENTAL SCIENCE & TECHNOLOGY
MU Faculty or unit

Faculty of Science

Citation
Web http://pubs.acs.org/doi/abs/10.1021/es502711c
Doi http://dx.doi.org/10.1021/es502711c
Field Water pollution and control
Keywords ENVIRONMENTAL RISK-ASSESSMENT; TANDEM MASS-SPECTROMETRY; SEWAGE-TREATMENT PLANTS; ZEBRAFISH DANIO-RERIO; RAINBOW-TROUT; WASTE-WATER; GLUCOCORTICOID-RECEPTOR; GENE-EXPRESSION; ONCORHYNCHUS-MYKISS; SURFACE WATERS
Description This study investigated the occurrence of corticosteroid signaling disruptors in wastewaters and rivers in the Czech Republic and in Switzerland. 36 target compounds were detected using HPLC-MS/MS, with up to 6.4 mu g/L for azole antifungals that indirectly affect corticosteroid signaling. Glucocorticoid receptor (GR)-mediated activity was determined using the GR-CALUX bioassay with dexamethasone equivalent concentrations ranging from
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