Analýza možností využití detekce gamaH2AX/53BP1 ohnisek a monitorování reparace dvouřetězcových zlomů DNA pro pre-terapeutické stanovení radiosensitivity nádorů hlavy a krku

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Title in English	Analysis of the use of detection gamaH2AX/53BP1 foci and monitoring of DNA double strand breaks repairs for pre-therapeutic evaluation of radiosensitivity of head and neck tumors
Authors	DEPEŠ Daniel FALK Martin MASAŘÍK Michal FALKOVÁ Iva GUMULEC Jaromír BAČÍKOVÁ Alena HORÁKOVÁ Zuzana PAGÁČOVÁ Eva BINKOVÁ Hana
Year of publication	2015
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Surgical management head and neck cancers is often devastating, it is therefore preferred noninvasive chemo / radiotherapy. We dont have marker identifying patients responsive to ionizing radiation before start of treatment. Primarydecision for the optimal therapy is therefore extremely important. Our goal is to optimize detection gammaH2AX/53BP1 foci using immunofluorescence microscopy for pretreament determination of the sensitivity of tumors head and neck to ionizing radiation in vitro.
Related projects:	Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii