Způsob přímé mono-N-substituce piperazinu

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Title in English	Method of direct mono-N-substitution of piperazine
Authors	PAZDERA Pavel ZBEROVSKÁ Barbora HEROVÁ Dana
Year of publication	2015
Type	Patent
MU Faculty or unit	Faculty of Science
Publisher	ÚPV Praha
State	Czech Republic
Patent's number	305317
Web	http://spisy.upv.cz/Patents/FullDocuments/305/305317.pdf
Description	In the present invention, there is disclosed a method of direct mono -N-substitution of piperazine in synthetically significant yields, wherein the method is characterized by preparation piperazine-1-cation and subsequently said piperazine-1-cation reacts under catalysis of a d-metal compound, aluminium or cerium and under conditions of Michael addition with an electrophilic reagent, preferably in molar ratio piperazine-1-cation to the electrophilic reagent in the range of 1:1 to 1:1,4.
Related projects:	New catalysts and reagents for sustainable green syntheses and combinatorial syntheses