Způsob přímé mono-N-substituce piperazinu

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Title in English Method of direct mono-N-substitution of piperazine
Authors

PAZDERA Pavel ZBEROVSKÁ Barbora HEROVÁ Dana

Year of publication 2015
Type Patent
MU Faculty or unit

Faculty of Science

Publisher ÚPV Praha
State Czech Republic
Patent's number 305317
Web http://spisy.upv.cz/Patents/FullDocuments/305/305317.pdf
Description In the present invention, there is disclosed a method of direct mono -N-substitution of piperazine in synthetically significant yields, wherein the method is characterized by preparation piperazine-1-cation and subsequently said piperazine-1-cation reacts under catalysis of a d-metal compound, aluminium or cerium and under conditions of Michael addition with an electrophilic reagent, preferably in molar ratio piperazine-1-cation to the electrophilic reagent in the range of 1:1 to 1:1,4.
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