Utilization of LA-ICP-MS for bioimaging

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Authors	VACULOVIČ Tomáš TVRDOŇOVÁ Michaela MASAŘÍK Michal POLANSKÁ Hana SVOBODOVÁ Markéta GUMULEC Jaromír KANICKÝ Viktor ČADKOVÁ Zuzana OTRUBA Vítězslav SZÁKOVÁ Jiřina
Year of publication	2016
Type	Appeared in Conference without Proceedings
MU Faculty or unit	Faculty of Science
Citation
Description	Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) represents one of the most suitable method for study of lateral distribution of specific elements (Cu, Zn, Pb, Pt...) in low concentration levels (tens mg/kg) in various biological tissues. Presented work is focused on study of influence of scan speed and laser spot diameter on lateral resolution, LOD, and time consumption of analysis. The utilization of LA-ICP-MS for bioimaging purpose will be demonstrated on two different types of the matrices. First one is tumour tissue which is treated by various Pt-based cytostatics (carbo-, oxali- and cis-Pt). The second one are cuts of tapeworm treated by various heavy metals.
Related projects:	CEITEC - Central European Institute of Technology Elemental mapping of plant and animal accumulators of heavy metals; where are they accumulated?