Electrospun Biodegradable PCL, PEG and PCL/PEG Polyurethane Nanofibers Coated by Amine-rich Plasma Polymers

Warning

This publication doesn't include Faculty of Education. It includes Central European Institute of Technology. Official publication website can be found on muni.cz.
Authors

KEDROŇOVÁ Eva KUPKA Vojtěch MANAKHOV Anton STOICA Adrian VOJTOVÁ Lucy ZAJÍČKOVÁ Lenka

Year of publication 2017
Type Article in Proceedings
Conference Nanocon 2016 - Proceedings
MU Faculty or unit

Central European Institute of Technology

Citation
Field Solid matter physics and magnetism
Keywords Electrospinning; Polymer nanofibers; Biomedical application; Plasma polymers; Amine Coatings
Description The electrospinning process was employed for preparation of nanofiber substrates made of polycaprolactone (PCL), polyethylene glycol (PEG) and polyurethane (PUR). The used polymer solution and electrospinning process influenced the structure and biodegradability of the resulting nanofibers. Materials processed from PCL and PEG were imaged as well-structured nanofiber meshes, however, processing of PUR resulted as an electrosprayed film rather than nanofibers structure most likely due to the insufficient molecular weight of PUR.In order to improve the biocompatibility of the nanofibers a thin amine layer by means of the cyclopropylamineplasma polymerization in radio frequency capacitively coupled discharge was deposited on prepared nanofibrous meshes. The presence of the amine groups is supposed to enhance the adhesion and proliferation of the cells. Moreover, the possibility for further functionalizing of such nanofibers was tested on a model PUR foil made of PCL and PEG. The PUR surface was activated with amine layer via similar procedure as the nanofibers and further the grafting of chitosan was employed through carbodiimide-mediated coupling. Infrared spectroscopy confirmed successful grafting of chitosan onto the PUR surface. Overcoming the drawback of PUR nanofibers processing, e.g. by synthesizing PUR with higher molecular weight, can open possible use of the material in wound healing applications exploiting antibacterial properties of chitosan.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.