hIAPP forms toxic oligomers in plasma

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Authors	CAMARGO D.C.R. GARG D. BUDAY K. FRANKO A. CAMARGO A.R. SCHMIDT F. COX S.J. SULADZE S. HASLBECK M. MIDEKSA Y.G. GEMMECKER G. AICHLER M. METTENLEITER G. SCHULZ M. WALCH A.K. DE ANGELIS M.H. FEIGE M.J. SIERRA C.A. CONRAD M. TRIPSIANES Konstantinos RAMAMOORTHY A. REIF B.
Year of publication	2018
Type	Article in Periodical
Magazine / Source	Chemical communications
MU Faculty or unit	Central European Institute of Technology
Citation
Doi	http://dx.doi.org/10.1039/c8cc03097a
Keywords	ISLET AMYLOID POLYPEPTIDE; INTRINSIC FLUORESCENCE; DIABETES-MELLITUS; TRANSGENIC MICE; INSULIN; AMYLIN; BETA; AGGREGATION; MECHANISM; FIBRILS
Description	In diabetes, hyperamylinemia contributes to cardiac dysfunction. The interplay between hIAPP, blood glucose and other plasma components is, however, not understood. We show that glucose and LDL interact with hIAPP, resulting in -sheet rich oligomers with increased -cell toxicity and hemolytic activity, providing mechanistic insights for a direct link between diabetes and cardiovascular diseases.
Related projects:	CEITEC 2020