SMC5/6: Multifunctional Player in Replication

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Authors

PALEČEK Jan

Year of publication 2019
Type Article in Periodical
Magazine / Source GENES
MU Faculty or unit

Faculty of Science

Citation
Web https://www.mdpi.com/2073-4425/10/1/7
Doi http://dx.doi.org/10.3390/genes10010007
Keywords SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination
Description The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6.
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