Stanovení hladiny psychofarmak metodou suché krevní skvrny- proveditelné v reálné praxi?
| Title in English | Determination of psychoactive drugs in dried blood spots- is it feasible in clinical practice? |
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| Authors | |
| Year of publication | 2021 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Advanced analytical methods today are very specific, sensitive and make it possible to determine substances in very low concentrations in various biological matrices. For a long time now, the application of these methods for determining the levels of drugs in dry blood spots has seemed attractive. However, the practical feasibility is limited by a number of factors (low sample volume (30-50 µl), matrix influence (hematocrit, hemoglobin, erythrocytes). Similarly, interpretation is hampered by the unclear relationship between capillary blood and plasma concentrations. |
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