Response to Vagal Stimulation by Heart-rate Features in Drug-resistant Epileptic Patients
| Authors | |
|---|---|
| Year of publication | 2020 |
| Type | Article in Proceedings |
| Conference | 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) |
| MU Faculty or unit | |
| Citation | |
| Web | https://ieeexplore.ieee.org/document/9176326/keywords#keywords |
| Doi | http://dx.doi.org/10.1109/EMBC44109.2020.9176326 |
| Keywords | Vagal Stimulation; Heart-rate Features;Drug-resistant Epileptic Patients |
| Description | Vagal Nerve Stimulation (VNS) is an option in the treatment of drug-resistant epilepsy. However, approximately a quarter of VNS subjects does not respond to the therapy. In this retrospective study, we introduce heart-rate features to distinguish VNS responders and non-responders. Standard pre-implantation measurements of 66 patients were segmented in relation to specific stimuli (open/close eyes, photic stimulation, hyperventilation, and rests between). Median interbeat intervals were found for each segment and normalized (NMRR). Five NMRRs were significant; the strongest feature achieved significance with p=0.013 and AUC=0.66. Low mutual correlation and independence on EEG signals mean that presented features could be considered as an addition for models predicting VNS response using EEG. |
| Related projects: |