Response to Vagal Stimulation by Heart-rate Features in Drug-resistant Epileptic Patients

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Authors

PLESINGER F. HALAMEK J. CHLÁDEK Jan JURAK P. DOLEŽALOVÁ Irena CHRASTINA Jan BRÁZDIL Milan

Year of publication 2020
Type Article in Proceedings
Conference 2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)
MU Faculty or unit

Faculty of Medicine

Citation
Web https://ieeexplore.ieee.org/document/9176326/keywords#keywords
Doi http://dx.doi.org/10.1109/EMBC44109.2020.9176326
Keywords Vagal Stimulation; Heart-rate Features;Drug-resistant Epileptic Patients
Description Vagal Nerve Stimulation (VNS) is an option in the treatment of drug-resistant epilepsy. However, approximately a quarter of VNS subjects does not respond to the therapy. In this retrospective study, we introduce heart-rate features to distinguish VNS responders and non-responders. Standard pre-implantation measurements of 66 patients were segmented in relation to specific stimuli (open/close eyes, photic stimulation, hyperventilation, and rests between). Median interbeat intervals were found for each segment and normalized (NMRR). Five NMRRs were significant; the strongest feature achieved significance with p=0.013 and AUC=0.66. Low mutual correlation and independence on EEG signals mean that presented features could be considered as an addition for models predicting VNS response using EEG.
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