Growth - associated protein (GAP-43) in terminal Schwann cells of rat Pacinian corpuscles
| Authors | |
|---|---|
| Year of publication | 1996 |
| Type | Article in Periodical |
| Magazine / Source | NeuroReport |
| MU Faculty or unit | |
| Citation | |
| Field | Other medical specializations |
| Keywords | sensory corpuscles |
| Description | GROWTH-ASSOCIATED protein (GAP-43) immunoreactivity was examined in Pacinian corpuscles of intact neonatal and adult rats as well as after denervation and reinnervation in adult rats. All immature Pacinian corpuscles were GAP-43 immunoreactive (GAP-43(+)) in their inner cores while only 46 +/- 5.6% of the mature corpuscles exhibited GAP-43(+) inner cores. The frequency of GAP-43(+) inner cores increased to 90 +/- 7.2% after their permanent denervation. The expression of GAP-43 in the inner cores was reduced by contact with regrowing axons, but 38 +/- 5.3% of Pacinian corpuscles retained GAP-43(+) in their inner cores following reinnervation. These results indicate that GAP-43 regulation is not confined only to axons but also involves some extra-axonal cues, and support a role for this protein in the process formation by terminal Schwann cells. |
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