The effect of potential carcinogen harman on selected cytochrome P450 enzymes in rats

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	KLÁSKOVÁ Eva STRAKOŠOVÁ Markéta JUŘICA Jan ZENDULKA Ondřej
Year of publication	2022
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Harman is a heterocyclic aromatic amine discovered in coffee, cigarette smoke, roasted meat, or fish. However, carcinogenic properties of harmane were proved - partly explained by its interaction via the AhR receptor and induction of CYP1A1. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of 75 % of drugs used in clinical practice. Our study aimed to determine the effects of harman on the most important CYP variants in a preclinical experiment.
Related projects:	Preklinický a klinický výzkum Farmakologického ústavu v oblasti farmakokinetiky, neurobiologie závislostí a personalizované farmakoterapie v onkologii