All-cause and cardiovascular mortality in relation to lung function in the full range of distribution across four Eastern European cohorts
| Authors | |
|---|---|
| Year of publication | 2022 |
| Type | Article in Periodical |
| Magazine / Source | Nature Scientific Reports |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.nature.com/articles/s41598-022-17261-5 |
| Doi | http://dx.doi.org/10.1038/s41598-022-17261-5 |
| Keywords | PULMONARY-FUNCTION; INCREASED RISK; FEV1; SPIROMETRY; PREDICTOR; INDIVIDUALS; ASSOCIATION; OUTCOMES; VALUES |
| Attached files | |
| Description | It is unclear whether the dose-response relationship between lung function and all-cause and cardiovascular mortality in the Central and Eastern European populations differ from that reported in the Western European and American populations. We used the prospective population-based HAPIEE cohort that includes randomly selected people with a mean age of 59 +/- 7.3 years from population registers in Czech, Polish, Russian and Lithuanian urban centres. The baseline survey in 2002-2005 included 36,106 persons of whom 24,944 met the inclusion criteria. Cox proportional hazards models were used to estimate the dose-response relationship between lung function defined as FEV1 divided by height cubed and all-cause and cardiovascular mortality over 11-16 years of follow-up. Mortality rate increased in a dose-response manner from highest to lower FEV1/height(3) deciles. Adjusted hazard ratios (HR) of all-cause mortality for persons in the 8th best, the 5th and the worst deciles were 1.27 (95% CI 1.08-1.49), 1.37 (1.18-1.60) and 2.15 (1.86-2.48), respectively; for cardiovascular mortality, the respective HRs were 1.84 (1.29-2.63), 2.35 (1.67-3.28) and 3.46 (2.50-4.78). Patterns were similar across countries, with some statistically insignificant variation. FEV1/height(3) is a strong predictor of all-cause and cardiovascular mortality, across full distribution of values, including persons with preserved lung function. |
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