Assessment of rate of major complications in transarterial chemoembolization using degradable starch microspheres versus permanent embolization particles in patients with hepatocellular carcinoma
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| Year of publication | 2022 |
| Type | Appeared in Conference without Proceedings |
| MU Faculty or unit | |
| Citation | |
| Description | Purpose: To analyze whether transarterial chemoembolization (TACE) using degradable starch microspheres (DSM-TACE) or permanent embolizing particles (DEB-TACE) cause significant difference in rate of major periprocedural complications in patients with hepatocellular carcinoma (HCC). Materials and methods: Prospective assessment of major periprocedural complications in 226 TACE procedures between 2018-2021 in 57 consecutive patients with HCC was performed. Study group consists of 110 DSM-TACE procedures, the control group consists of 116 procedures using permanent embolizing particles. Major complications were followed up to 30 days after each TACE (contrast-enhanced CT, laboratory parameters, clinical status). Our data underwent statical analyses (chi-squared test). Results: There was significant difference in complication per procedure in the study and the control group (3% vs 14% p=0,006). Complications after TACE included severe postembolization syndrome (n=11), liver ischemia caused by reflux of permanent particles (n=4), liver abscess (n=2), cholangitis (n=2), allergic reaction (n=1). Conclusion: Patients with HCC treated with TACE using permanent embolization particles have significantly higher frequency of major postprocedural complication compared to patients with HCC treated with TACE using degradable particles. |
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