In vivo and in vitro effects of salidroside on liver cytochrome P450

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Authors

KLÁSKOVÁ Eva JUŘICA Jan HAMMER Tomáš MÁCHALOVÁ Alena MLČŮCHOVÁ Natálie VYKLICKÁ Kateřina BRENEROVÁ Petra BOŘILOVÁ LINHARTOVÁ Petra ZENDULKA Ondřej

Year of publication 2022
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Salidroside (SAL) is one of the main active compounds of Rhodiola rosea, a herb with antidepressant and anxiolytic potential proven by clinical studies. Cytochromes P450 (CYP) are enzymes responsible for the metabolism of 70-80 % of medicaments in clinical practice. Since R. rosea is the ingredient of various over-the-counter food supplements, we have focused on its potential for pharmacokinetic interactions with the most important CYP isoforms.
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