Predictive factors of multiple sclerosis relapse after the first demyelinating event: A 5-year follow-up

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Authors

KOLČAVA Jan PELÍŠEK Ondřej VLČKOVÁ Eva

Year of publication 2023
Type Article in Periodical
Magazine / Source MULTIPLE SCLEROSIS AND RELATED DISORDERS
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S2211034823000706?via%3Dihub
Doi http://dx.doi.org/10.1016/j.msard.2023.104566
Keywords Clinically isolated syndrome; Magnetic resonance imaging; Multiple sclerosis; Oligoclonal bands; Demyelinating diseases
Description There is a growing need to discover the characteristics that predict prognostic factors after the first demyelin-ating event. In this study of 141 patients that met the 2017 McDonald criteria, a higher number of oligoclonal bands, cervical spinal cord demyelinating lesions, and sensory involvement were identified as independent predictors of the second demyelinating event during the 5-year follow-up period in patients who experienced the first demyelinating event. The identification of the aforementioned risk variables will make it possible to identify patients who are more likely to exhibit early second demyelinating event, implying more frequent monitoring and consideration of early application of highly effective disease-modifying treatment.
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