Těhotenství komplikované gestačním diabetem a preeklampsií – společný patofyziologický mechanismus?
| Title in English | Pregnancy complicated by gestational diabetes and preeclampsia – a common pathophysiological mechanism? |
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| Authors | |
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | Diabetologie, metabolismus, endokrinologie, výživa |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.tigis.cz/component/k2/item/1493-dmev-3-2023 |
| Keywords | diabetes; pregnnacy; preeclampsy |
| Description | Gestational diabetes mellitus (GDM) represents a relatively frequent complication of pregnancy, which has an impact on both the course of the current pregnancy and childbirth, as well as for the long-term metabolic health of the mother and her child. The reported incidence of GDM varies around 14% worldwide (9–24% in the Czech Republic), depending on the diagnostic criteria used. Preeclampsia (PE) is one of the rare pregnancy complications with the incidence about 2–8% worldwide (4–6% in the Czech Republic), but its impact on ongoing pregnancy can be very serious and in the past – in the form of eclampsia – even fatal. The aim of this review article is to summarize the current knowledge of the etiopathogenesis of both pregnancy complications, i.e. (1) GDM and (2) PE. Furthermore, (3) we aim to present the epidemiological data on isolated and parallel occurrence of GDM and PE and the pitfalls of their diagnostics (e.g. inconsistent criteria or screening systems) and (4) to discuss pathophysiological mechanisms responsible for concurrent manifestation of GDM and PE. |
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