Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use

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Authors	KOVÁCSOVÁ Flóra FOLBER František WEINBERGEROVÁ Barbora ŠTĚPÁNOVÁ Radka KABUT Tomáš TOMÍŠKA Miroslav KREJČÍ Marta MAYER Jiří
Year of publication	2023
Type	Article in Periodical
Magazine / Source	Annals of hematology
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://link.springer.com/article/10.1007/s00277-023-05479-w
Doi	http://dx.doi.org/10.1007/s00277-023-05479-w
Keywords	Acute and chronic GVHD; AlloHSCT; ATG Grafalon
Attached files	Low_incidence_of_severe_acute_and_chronic_graft-versus-host_disease_in_a_long-term_retrospective_study_with_ATG_Grafalon_routine_use.pdf
Description	Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department's base of peri-transplant supportive care. This recent retrospective study included 398 patients who underwent their first allogeneic hematopoietic stem cell transplantation after receiving a defined dose of ATG Grafalon. Our observations recorded reduced incidence of severe acute and chronic GVHD without negative impact on overall survival in a nonselected group with standard and uniform GVHD prophylaxis.
Related projects:	National institute for cancer research