Prenatal MAM exposure raises kynurenic acid levels in the prefrontal cortex of adult rats

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Authors	FRESCURA Francesca ŠTARK Tibor TIZIANI Edoardo DI MARTINO Serena RUDÁ Jana DRAGO Filippo FERRARO Luca MICALE Vincenzo BEGGIATO Sarah
Year of publication	2024
Type	Article in Periodical
Magazine / Source	PHARMACOLOGICAL REPORTS
MU Faculty or unit	Faculty of Medicine
Citation
web	https://link.springer.com/article/10.1007/s43440-024-00604-6
Doi	http://dx.doi.org/10.1007/s43440-024-00604-6
Keywords	AM251;Novel object recognition test;Kynurenine Pathway;Haloperidol;Peripubertal treatment;Schizophrenia
Description	The present findings suggest that the cognitive deficit observed in MAM rats may be related to enhanced PFC KYNA levels which could be, in turn, mediated by the activation of cannabinoid CB1 receptor. These results further support the modulation of brain KYNA levels as a potential therapeutic strategy to ameliorate the cognitive dysfunctions in schizophrenia.
Related projects:	Preclinical and clinical research of the Department of Pharmacology in the field of biotransformation of drugs, behavioural neuropsychopharmacology and personalized pharmacotherapy in oncology